Can A Non Inferiority Trial Show Superiority. By contrast non-inferiority trials tend to reward the careless. In some situations the new treatment may not be superior to the existing treatment at all if so it will be impossible to show it is superior.
Proving that two treatments are equal in performance is impossible with statistical tools. Noninferior and Superior Experimental treatment is found to be better than the control. At the conclusion of a non-inferiority experiment the confidence interval can be plotted and examined on a chart showing the non-inferiority margin representing the non-inferiority difference between X and Y.
Improper handling of missing data can benefit a more toxic less efficacious treatment potentially increasing the possibility of a false finding in a superiority trial.
In comparison studies with a current therapy non-inferiority is used to demonstrate that the new therapy provides at least the same benefit to the patient. Jul 09 2019 One can also declare superiority in a non-inferiority trial if the lower limit of CI of the new treatment is above the non-inferiority margin and above zero. Inferiority while the results of a non-inferiority trial may appear to support superiority. Equivalence trials aim to show the new treatment is no better and no worse.
