Calculator Sample Size Non Inferiority. Calculate Sample Size Needed to Compare 2 Proportions. Here a type- I error occurs when you falsely conclude non-inferiority.
4 6 Conceptually it is calculated what sample size is needed to prove with statistical significance and a certain power that the loss of therapeutic effect of the new therapy compared to the standard therapy is not larger than what. Epub 2015 Nov 25. You may enter a range of values such as 10 to 100 by 10.
If an appropriate margin has been chosen a confidence interval that lies entirely between and 0.
Practical guide to sample size calculations. If an appropriate margin has been chosen a confidence interval that lies entirely between and 0. Authors Laura Flight 1 Steven A Julious 1 Affiliation 1 Medical Statistics Group The University of Sheffield. The new drug will be considered non-inferior if the mean number of steps is not more than 12 steps lower than standard of care with 80 power and a significance level of 5.
