Animal Experiment Sample Size Calculator. For example in an experiment to study the effect of a drug on tumor sizes in a group of animals at four time points pre-treatment and. This free sample size calculator determines the sample size required to meet a given set of constraints.
Researchers are routinely asked to justify the number of animals used in their studies either by regulatory bodies funding agencies or increasingly by journal editorsIn accordance with the 3Rs studies should be designed to reduce the number of animals used to meet scientific objectives. Below are some information and resources that explain the reasons why sample size calculation is important and we hope that will assist you with your AEEC applications. The planned number of experimental units relates to the sample size determined in the planning stages before the experiment is conducted.
The sample size calculator supports experiments in which one is gathering data on a single sample in order to compare it to a general population or known reference value one-sample as well as ones where a control group is compared to one or more treatment groups two-sample k-sample in order to detect differences between them.
Proper sample size calculation is both a scientific and ethical imperative. The structure of the experiment The method for analyzing the data The size of the true underlying effect The variability in the measurements The chosen significance level α The sample size Note. Sample Size Calculating accurate group sizes are important both for scientific validity as well as animal welfare. Dell Steve Holleran and Rajasekhar Ramakrishnan Abstract Scientists who use animals in research must justify the num-ber of animals to be used and committees that review pro-posals to use animals in research must review this justification to ensure the appropriateness of the number of animals to be used.
